Supplements
Methylfolate (5-MTHF, Active Folate)
The active, body-ready form of folate that skips the MTHFR bottleneck
Methylation
Supplements
SAM-e (S-Adenosylmethionine)
A methylation compound with evidence for mood, joint comfort, and liver health — but serious antidepressant interactions
Blog
TMG (Betaine): What the Research Actually Supports
One of the few supplements with a clean, replicated biomarker effect — and a cholesterol caveat nobody puts on the label
Supplements
TMG/Betaine (Trimethylglycine)
The methyl donor that supports cardiovascular health, detoxification, and cellular energy production
Guides
Folate Explained: Folic Acid, Methylfolate, and What This B Vitamin Actually Does
One vitamin, three names, and more confusion per microgram than almost any other nutrient.
Supplements
Vitamin B12 (Cobalamin)
The methylation and energy cofactor for neurological function, DNA synthesis, and red blood cells
Supplements
Vitamin B9 (Folate)
The one-carbon metabolism cofactor for DNA synthesis, methylation, and neurological health
Guides
Methylation Explained: The Nutrients Behind Your Body's Busiest Chemical Reaction
One methyl group, a billion reactions a second, and a whole industry of overselling.