Depression

Supplements

Saffron

Standardized saffron extract for mood, mild low mood, and appetite — antidepressant-comparable in small trials, but an adjunct only

Supplements

SAM-e (S-Adenosylmethionine)

A methylation compound with evidence for mood, joint comfort, and liver health — but serious antidepressant interactions

Supplements

St. John's Wort

An evidence-backed mood herb with serious drug interactions — caveats first, always