Interaction Guide
Supplements to Take (and Avoid) with Adderall
Which supplements are safe with Adderall? Guide to reducing side effects, supporting focus, and avoiding dangerous stimulant interactions for ADHD …
Supplement & Medication Interactions
Find out which supplements are safe, beneficial, or risky with your medications
Medical Disclaimer
This information is for educational purposes only. Always consult your healthcare provider before combining supplements with medications.
Detailed Interaction Guides
Interaction Guide
Supplements to Take (and Avoid) with Antibiotics
Which supplements are safe with antibiotics? Probiotic timing guide, mineral interactions, and how to protect your gut during antibiotic treatment.
Interaction Guide
Supplements to Take (and Avoid) with Benzodiazepines
Which supplements are safe with Xanax, Valium, and Klonopin? Guide to avoiding dangerous sedation, supporting anxiety, and safe benzodiazepine …
Interaction Guide
Supplements to Take (and Avoid) with Beta-Blockers
Which supplements are safe with metoprolol, atenolol, and propranolol? CoQ10 depletion, melatonin support, and beta-blocker supplement interaction …
Interaction Guide
Supplements to Take (and Avoid) with Birth Control
Which supplements are safe with birth control pills? Guide to nutrient depletion from oral contraceptives and supplements that reduce birth control …
Interaction Guide
Supplements to Take (and Avoid) with Blood Pressure Medications
Which supplements are safe with blood pressure medications? Guide to CoQ10, magnesium, and supplements that lower or raise blood pressure.
Interaction Guide
Supplements to Take (and Avoid) with Levothyroxine
Which supplements are safe with levothyroxine (Synthroid)? Critical 4-hour mineral rule, thyroid conversion support, and evidence-based interaction …
Interaction Guide
Supplements to Take (and Avoid) with Metformin
Which supplements are safe with metformin? Essential guide to B12 depletion, nutrient interactions, and the best supplements for metformin users.
Interaction Guide
Supplements to Take (and Avoid) with NSAIDs
Which supplements are safe with ibuprofen and naproxen? Guide to natural anti-inflammatories, gut protection, and NSAID supplement interactions.
Interaction Guide
Supplements to Take (and Avoid) with PPIs
Which supplements are safe with PPIs like omeprazole and pantoprazole? Guide to nutrient depletion, absorption issues, and the best supplements for …
Interaction Guide
Supplements to Take (and Avoid) with SSRIs
Which supplements are safe with SSRIs like Lexapro and Zoloft? Evidence-based guide to SSRI supplement interactions.
Interaction Guide
Supplements to Take (and Avoid) with Statins
Which supplements are safe with statins like Lipitor and Crestor? CoQ10 depletion, muscle pain relief, and evidence-based statin supplement guide.
Interaction Guide
Supplements to Take (and Avoid) with Steroids (Prednisone)
Which supplements are safe with prednisone and corticosteroids? Bone protection, mineral depletion, and immune support guide for steroid users.
Interaction Guide
Supplements to Take (and Avoid) with Thyroid Medications
Which supplements are safe with thyroid medications? Critical timing rules, mineral interactions, and the best supplements for thyroid health.
Interaction Guide
Supplements to Take (and Avoid) with Warfarin
Which supplements are safe with warfarin (Coumadin)? Critical guide to vitamin K interactions, bleeding risk, and safe supplement choices for blood …
Quick Reference: All Medication Interactions
Adderall (ADHD)
Category: Stimulant
Magnesium
Omega-3 Fish Oil
L-Theanine
B-Complex
Vitamin D3
Zinc
Vitamin C (timing matters)
Melatonin
Iron
Caffeine Supplements
Ginseng
Yohimbe
Timing: Take supplements 2+ hours away from Adderall. Take vitamin C in the evening only. Magnesium at bedtime helps with sleep.
Antibiotics
Category: Antimicrobial
Probiotics
B-Complex
Vitamin C
Vitamin D3
Vitamin K
Zinc
Iron
Calcium (with fluoroquinolones)
Magnesium (with fluoroquinolones)
Timing: Take probiotics at least 2 hours away from antibiotic doses. Continue probiotics for at least 7-14 days after finishing the antibiotic course.
Benzodiazepines (Xanax, Valium, Klonopin)
Category: Anxiolytic/Sedative
Magnesium
B-Complex
Omega-3 Fish Oil
Vitamin D3
Probiotics
L-Theanine
Melatonin
CBD
Kava
Valerian Root
GABA Supplements
Phenibut
Timing: Do NOT combine with any sedating supplements. If you currently take sedating supplements and are starting a benzodiazepine, inform your doctor immediately.
Beta-Blockers (Metoprolol, Atenolol, Propranolol)
Category: Antihypertensive
CoQ10
Melatonin
Magnesium
Vitamin D3
Omega-3 Fish Oil
B-Complex
Potassium
Hawthorn Berry
Garlic Supplements
High-Dose Calcium
Ephedra/Ma Huang
Bitter Orange (Synephrine)
Timing: Take CoQ10 with meals for absorption. Melatonin at bedtime to restore sleep disrupted by beta-blockers.
Birth Control Pills
Category: Hormonal Contraceptive
B-Complex
Magnesium
Zinc
Vitamin C
Omega-3 Fish Oil
Vitamin D3
Probiotics
DIM (Diindolylmethane)
Vitex (Chasteberry)
St. John's Wort
Activated Charcoal
Timing: Take supplements with meals. Avoid activated charcoal within 3 hours of birth control pill.
Blood Pressure Medications
Category: Antihypertensive
CoQ10
Magnesium
Omega-3 Fish Oil
Vitamin D3
Probiotics
B-Complex
Potassium
Hawthorn Berry
Garlic Supplements
Licorice Root
Ephedra/Ma Huang
Yohimbe
Timing: Take magnesium in the evening; it may enhance the nighttime BP-lowering effect. Monitor BP regularly when adding supplements.
Levothyroxine (Hypothyroidism)
Category: Thyroid Hormone
Selenium
Zinc
Vitamin D3
Vitamin B12
Omega-3 Fish Oil
Iodine
Ashwagandha
L-Tyrosine
Calcium (within 4 hours)
Iron (within 4 hours)
Magnesium (within 4 hours)
Soy Isoflavones
Timing: CRITICAL: Take levothyroxine first thing in the morning on an empty stomach with water only. Wait 30-60 minutes before eating. Wait 4+ hours before taking ANY mineral supplement.
Metformin (Diabetes)
Category: Antidiabetic
Vitamin B12
Folate
Vitamin D3
Magnesium
Chromium
Omega-3 Fish Oil
Alpha-Lipoic Acid
CoQ10
Berberine
Cinnamon Extract
Alcohol-Based Tinctures
Bitter Melon
Timing: Take B12 and folate at least 2 hours apart from metformin for optimal absorption. Take metformin with meals.
NSAIDs (Ibuprofen, Naproxen)
Category: Pain/Anti-inflammatory
Omega-3 Fish Oil
Curcumin (Turmeric)
Probiotics
Vitamin C
Folate
Vitamin D3
Iron
Ginger
White Willow Bark
Aspirin or Other NSAIDs
High-Dose Vitamin E
Timing: Take NSAIDs with food to protect the stomach. Omega-3 and curcumin taken regularly may reduce NSAID dependence over time.
PPIs (Acid Reflux)
Category: Proton Pump Inhibitor
Vitamin B12
Magnesium
Calcium
Iron
Vitamin C
Probiotics
Vitamin D3
Zinc
Digestive Enzymes
Apple Cider Vinegar
Betaine HCl
High-Dose Mineral Blends
Timing: Take ALL supplements at least 2 hours after your PPI dose. Use sublingual B12 and chelated mineral forms for better absorption.
SSRIs (Antidepressants)
Category: Antidepressant
Omega-3 Fish Oil
Magnesium
B-Complex
Vitamin D3
Zinc
Probiotics
Vitamin C
SAMe
Melatonin
Curcumin
St. John's Wort
5-HTP
L-Tryptophan
Timing: Take supplements with meals for consistent absorption. Maintain a regular schedule alongside your SSRI.
Statins (Cholesterol)
Category: Cholesterol-Lowering
CoQ10
Vitamin D3
Omega-3 Fish Oil
Vitamin K2
Magnesium
Probiotics
Niacin (Vitamin B3)
Vitamin A
Citrus Bergamot
Red Yeast Rice
Grapefruit Extract
St. John's Wort
Timing: Take CoQ10 with a fat-containing meal for absorption. If taking a statin at night, take CoQ10 earlier in the day.
Steroids (Prednisone, etc.)
Category: Corticosteroid
Calcium
Vitamin D3
Magnesium
Zinc
Vitamin C
Probiotics
B-Complex
Potassium
Melatonin
DHEA
High-Dose Vitamin A
Echinacea
Timing: Long-term steroid use requires bone density monitoring. Start calcium + D3 supplementation immediately when beginning steroid therapy.
Thyroid Medications
Category: Hormone Replacement
Selenium
Zinc
Vitamin D3
B-Complex
Omega-3 Fish Oil
Iodine
Ashwagandha
Calcium (within 4 hours)
Iron (within 4 hours)
Magnesium (within 4 hours)
Timing: CRITICAL: Take thyroid medication on an empty stomach, 30-60 minutes before food. Wait at least 4 hours before taking any mineral supplements.
Warfarin (Blood Thinner)
Category: Anticoagulant
Vitamin D3
Probiotics
Vitamin C
B-Complex
Omega-3 Fish Oil
Magnesium
CoQ10
Vitamin K Supplements
Garlic Supplements
Ginkgo Biloba
High-Dose Ginger
Timing: CONSULT YOUR DOCTOR before taking ANY new supplement. Maintain consistent vitamin K dietary intake. Have INR checked after any supplement changes.
Interaction Legend
Safe — Beneficial or no interaction
Caution — May interact, use under supervision
Avoid — Dangerous interaction risk